| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T86273 | ||||
| Target Name | G-protein coupled bile acid receptor 1 (GPBAR1) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Bile acid | Drug Info | IC50 = 140 nM | [1] | |
| References | |||||
| REF 1 | Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21. | ||||
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