| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T88338 | ||||
| Target Name | Bacterial 23S ribosomal RNA (Bact 23S rRNA) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Linezolid | Drug Info | IC50 = 0.6 mcg/ml | [2] | |
| Action against Disease Model | Macrolides | Drug Info | IC50 on translation in Staphylococcus aureus cells: 200 ng/mL | [1] | |
| References | |||||
| REF 1 | A combination of roxithromycin and imipenem as an antimicrobial strategy against biofilms formed by Staphylococcus aureus. J Antimicrob Chemother. 2001 Oct;48(4):573-7. | ||||
| REF 2 | Bacterial ribosomal subunit assembly is an antibiotic target. Curr Top Med Chem. 2003;3(9):929-47. | ||||
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