Target Validation Information
TTD ID	T89918
Target Name	Glycinamide ribonucleotide formyltransferase (GART)
Type of Target	Clinical trial
Drug Potency against Target	10-trifluoroacetyl-DDACTHF	Drug Info	Ki = 30 nM	[1]
	DDATHF	Drug Info	IC50 = 780 nM	[3]
	Dideazaacyclotetrahydrofolic acid	Drug Info	Ki = 1700 nM	[2]
	Dideazafolate	Drug Info	Ki = 2000 nM	[4]
References
REF 1	Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem. 2006 May 18;49(10):2998-3002.
REF 2	Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 2008 Sep 11;51(17):5441-8.
REF 3	Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis ... J Med Chem. 2010 Feb 11;53(3):1306-18.
REF 4	N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 1987 Jul;30(7):1254-6.

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