| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T91480 | ||||
| Target Name | ATP-binding cassette transporter C8 (ABCC8) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Glimepiride | Drug Info | IC50 = 3.0 nM | [1] | |
| Repaglinide | Drug Info | IC50 = 2~8 nM/l | [2] | ||
| References | |||||
| REF 1 | Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels. Br J Pharmacol. 2001 May;133(1):193-9. | ||||
| REF 2 | Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels. Diabetologia. 2001 Jun;44(6):747-56. | ||||
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