| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T91661 | ||||
| Target Name | Adenosine kinase (ADK) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | 5-iodo,5'-deoxytubercidin | Drug Info | IC50 = 0.9 nM | [1] | |
| 6-Benzylthioinosine | Drug Info | Ki = 14300 nM | [2] | ||
| References | |||||
| REF 1 | Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. J Med Chem. 2006 Nov 16;49(23):6726-31. | ||||
| REF 2 | Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Bioorg Med Chem. 2010 May 15;18(10):3403-12. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.