Target Validation Information
TTD ID	T92521
Target Name	Cytochrome P450 1B1 (CYP1B1)
Type of Target	Clinical trial
Drug Potency against Target	2-[2-(3,5-Dimethoxy-phenyl)-vinyl]-thiophene	Drug Info	IC50 = 2 nM	[1]
	3-[2-(3,5-Dimethoxy-phenyl)-vinyl]-furan	Drug Info	IC50 = 2100 nM	[1]
	4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-pyridine	Drug Info	IC50 = 460 nM	[1]
	ACACETIN	Drug Info	IC50 = 12 nM	[2]
	APIGENIN	Drug Info	IC50 = 25 nM	[2]
	Chrysin	Drug Info	IC50 = 24 nM	[2]
	CHRYSOERIOL	Drug Info	IC50 = 20 nM	[2]
	DIOSMETIN	Drug Info	IC50 = 29 nM	[2]
	ERIODICTYOL	Drug Info	IC50 = 1284 nM	[2]
	Galangin	Drug Info	IC50 = 25 nM	[2]
	HOMOERIODICTYOL	Drug Info	IC50 = 1716 nM	[2]
	ISORHAMNETIN	Drug Info	IC50 = 17 nM	[2]
	ISOSAKUTANETIN	Drug Info	IC50 = 1024 nM	[2]
	KAEMPFERIDE	Drug Info	IC50 = 25 nM	[2]
	KAEMPFEROL	Drug Info	IC50 = 47 nM	[2]
	N-(2,4-Dimethoxy-phenyl)-3,5-dimethoxy-benzamide	Drug Info	IC50 = 670 nM	[1]
	NARINGENIN	Drug Info	IC50 = 3656 nM	[2]
	PINOCEMBRIN	Drug Info	IC50 = 1679 nM	[2]
	TAMARIXETIN	Drug Info	IC50 = 20 nM	[2]
	TRISMETHOXYRESVERATROL	Drug Info	IC50 = 790 nM	[1]
References
REF 1	Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4.
REF 2	Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5.

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