Target Validation Information
TTD ID	T92640
Target Name	Lysophosphatidic acid receptor 1 (LPAR1)
Type of Target	Clinical trial
Drug Potency against Target	(1,1-Difluoro-pentadecyl)-phosphonic acid	Drug Info	Ki = 788 nM	[1]
	Decyl-phosphonic acid	Drug Info	IC50 = 3122 nM	[1]
	Dodecyl-phosphonic acid	Drug Info	IC50 = 2638 nM	[1]
	dodecyl-thiophosphate	Drug Info	IC50 = 2838 nM	[1]
	Phosphoric acid mono-((E)-dec-4-enyl) ester	Drug Info	IC50 = 1300 nM	[1]
	Phosphoric acid mono-((E)-dodec-9-enyl) ester	Drug Info	IC50 = 916 nM	[1]
	Phosphoric acid mono-((E)-tetradec-11-enyl) ester	Drug Info	Ki = 457 nM	[1]
	Phosphoric acid mono-((E)-tetradec-9-enyl) ester	Drug Info	Ki = 1146 nM	[1]
	Phosphoric acid monodec-9-enyl ester	Drug Info	IC50 = 1510 nM	[1]
	Phosphoric acid monododecyl ester	Drug Info	Ki = 1354 nM	[1]
	Phosphoric acid monotetradecyl ester	Drug Info	Ki = 1082 nM	[1]
	Tetradecyl-phosphonic acid	Drug Info	IC50 = 9674 nM	[1]
	Thiophosphoric acid (E)-dodec-9-enyl ester	Drug Info	IC50 = 2972 nM	[1]
	Thiophosphoric acid (E)-tetradec-9-enyl ester	Drug Info	IC50 = 938 nM	[1]
	Thiophosphoric acid dec-9-enyl ester	Drug Info	IC50 = 1000 nM	[1]
	Thiophosphoric acid decyl ester	Drug Info	IC50 = 1220 nM	[1]
References
REF 1	Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30.

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