Target Validation Information
TTD ID	T93105
Target Name	Presenilin 1 (PSEN1)
Type of Target	Clinical trial
Drug Potency against Target	(2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone	Drug Info	IC50 = 13900 nM	[3]
	(5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone	Drug Info	IC50 = 1600 nM	[3]
	(5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone	Drug Info	IC50 = 10200 nM	[3]
	1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one	Drug Info	IC50 = 1000 nM	[3]
	1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene	Drug Info	IC50 = 461 nM	[2]
	Drug 311383	Drug Info	IC50 = 14 nM	[1]
	Drug 311440	Drug Info	IC50 = 9 nM	[1]
	Drug 311951	Drug Info	IC50 = 16 nM	[1]
	Drug 311952	Drug Info	IC50 = 26 nM	[1]
References
REF 1	Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3.
REF 2	Aryl sulfones: a new class of gamma-secretase inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8.
REF 3	Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6.

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