| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T94400 | ||||
| Target Name | Mycobacterium Thymidine monophosphate kinase (MycB tmk) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 5'-amino-5'-deoxy-alpha-D-thymidine | Drug Info | Ki = 16000 nM | [1] | |
| BROMODEOXYURIDINE | Drug Info | Ki = 5000 nM | [2] | ||
| CHLORODEOXYURIDINE | Drug Info | Ki = 10000 nM | [2] | ||
| References | |||||
| REF 1 | Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacteri... J Med Chem. 2007 Nov 1;50(22):5281-92. | ||||
| REF 2 | Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. | ||||
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