Target Validation Information
TTD ID	T99616
Target Name	Trypanosoma Trypanothione reductase (Trypano TPR)
Type of Target	Successful
Drug Potency against Target	1-(2'-chlorophenyl)penta-1,4-dien-3-one	Drug Info	IC50 = 2000 nM	[1]
	CEPHARANTINE	Drug Info	Ki = 7600 nM	[3]
	N-(5-chloro-2-(phenylthio)phenyl)butyramide	Drug Info	Ki = 11300 nM	[2]
	N1,N2-bis(dihydrocaffeoyl)spermine	Drug Info	Ki = 13000 nM	[3]
References
REF 1	Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.
REF 2	Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class ... J Med Chem. 2005 Dec 15;48(25):8087-97.
REF 3	The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95.

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