Target Validation Information
TTD ID	T99740
Target Name	Myb messenger RNA (MYB mRNA)
Type of Target	Clinical trial
Action against Disease Model	LR3001	Drug Info	Neuroblastoma cell proliferation was inhibited to a greater extent by GD2-targeted liposomes containing c-myb asODNs (including LR3001) than by nontargeted liposomes or free asODNs. GD2-targeted liposomes containing c-myb asODNs specifically reduced xpression of c-Myb protein by neuroblastoma cells. Enhanced liposome binding and asODN uptake, as well as the antiproliferative	[1]
References
REF 1	Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: antitumor effects. J Natl Cancer Inst. 2000 Feb 2;92(3):253-61.

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