Target Information

Target General Information

Target ID

T08218 (Former ID: TTDR00023)

Target Name

Mycobacterium DTDP-dehydrorhamnose epimerase rmlC (MycB rmlC)

Synonyms

dTDP-L-rhamnose synthase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-4-dehydrorhamnose 3,5-epimerase; Thymidine diphospho-4-keto-rhamnose 3,5-epimerase

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Gene Name

MycB rmlC

Target Type

Literature-reported target

[1]

Function

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.

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BioChemical Class

Racemases and epimerases

UniProt ID

RMLC_MYCTU

EC Number

EC 5.1.3.13

Sequence

MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNCSVSSAGVLRG
LHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHG
FLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGAAPSLSDRDAAAPSFEDV
RASGLLPRWEQTQRFIGEMRGT

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3D Structure

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PDB

Drug Binding Sites of Target

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Ligand Name: 2'-Deoxy-thymidine-beta-L-rhamnose

Ligand Info

Structure Description

RmlC M. tuberculosis with dTDP-rhamnose

PDB:2IXC

Method

X-ray diffraction

Resolution

1.79 Å

Mutation

[2]

PDB Sequence

MKARELDVPG

¹⁰

AWEITPTIHV

²⁰

DSRGLFFEWL

³⁰

TDHGFRAFAG

⁴⁰

HSLDVRQVNC

⁵⁰

SVSSAGVLRG

⁶⁰

LHFAQLPPSQ

⁷⁰

AKYVTCVSGS

⁸⁰

VFDVVVDIRE

⁹⁰

GSPTFGRWDS

¹⁰⁰

VLLDDQDRRT

¹¹⁰

IYVSEGLAHG

¹²⁰

FLALQDNSTV

¹³⁰

MYLCSAEYNP

¹⁴⁰

QREHTICATD

¹⁵⁰

PTLAVDWPLV

¹⁶⁰

DGAAPSLSDR

¹⁷⁰

DAAAPSFEDV

¹⁸⁰

RASGLLPRWE

¹⁹⁰

QTQRFIGE

Residue

Distance (Å)

GLN47

3.338

ASN49

3.162

SER51

4.590

ARG59

2.944

GLY60

4.318

HIS62

2.692

GLN70

3.806

LYS72

2.670

HIS119

2.685

Residue

Distance (Å)

GLY120

3.909

PHE121

4.240

TYR132

3.278

TYR138

3.106

GLU143

3.960

SER168

4.342

ARG170

3.453

ASP171

3.864

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Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

There is no similarity protein (E value < 0.005) for this target

References

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REF 1

How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

REF 2

RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol. 2007 Jan 5;365(1):146-59.

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