Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Target Regulators
References
Drug Binding Sites of Target  Top
Ligand Name: Uridine-5'-Diphosphate Ligand Info
Structure Description Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13 PDB:5AJP
Method X-ray diffraction Resolution 1.65 Å Mutation Yes [2]
PDB Sequence
TTPSPVPTTS
11
TTSAA
Residue
Distance (Å)
PRO4
3.233
Residue
Distance (Å)
SER5
2.676
Ligand Name: N-Acetyl-2-deoxy-2-amino-galactose Ligand Info
Structure Description Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-3,13 PDB:5AJO
Method X-ray diffraction Resolution 1.48 Å Mutation Yes [2]
PDB Sequence
AGTTPSPVPT
9
TSTTSAA
Residue
Distance (Å)
THR2
3.814
THR3
1.421
PRO4
3.595
SER5
2.537
PRO6
3.908
Residue
Distance (Å)
SER11
3.122
THR13
1.409
SER14
3.543
ALA15
3.395
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Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
Protein Name Pfam ID Percentage of Identity (%) E value
Proteoglycan 4 (PRG4)
PF00045 ; 
PF01033
36.307 (175/482) 1.32E-11
Mucin-1 (MUC1)
PF01390
30.300 (273/901) 2.16E-11
Filamin-A-interacting protein 1 (FILIP1)
PF09727
23.810 (85/357) 9.46E-10
Helicase SRCAP (SRCAP)
PF00271 ; 
PF07529 ; 
PF00176
More >>
 25.783 (140/543) 5.09E-08
MAP7 domain-containing protein 3 (MAP7D3)
PF05672
24.607 (47/191) 2.03E-05
Kinesin-like protein KIF13B (KIF13B)
PF01302 ; 
PF12473 ; 
PF00498 ; 
PF12423 ; 
PF00225 ; 
PF16183
More >>
 23.308 (62/266) 7.87E-05
Extracellular matrix organizing protein FRAS1 (FRAS1)
PF16184 ; 
PF03160 ; 
PF00093
More >>
 29.545 (52/176) 1.03E-04
Neurofilament heavy polypeptide (NEFH)
PF07142 ; 
PF00038
14.556 (77/529) 1.00E-03
Collagen alpha-1(XXVII) chain (COL27A1)
PF01410 ; 
PF01391
30.385 (79/260) 2.00E-03
Dynactin subunit 1 (DCTN1)
PF01302 ; 
PF12455
31.897 (37/116) 2.00E-03
Probable maltase-glucoamylase 2 (MGAM2)
PF13802 ; 
PF01055 ; 
PF16863 ; 
PF00088
More >>
 28.840 (184/638) 4.00E-03
UV excision repair protein RAD23 homolog B (RAD23B)
PF00627 ; 
PF00240 ; 
PF09280
More >>
 31.373 (32/102) 4.00E-03
Melanoma-associated antigen E1 (MAGEE1)
PF01454
31.905 (134/420) 5.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
IL-17 signaling pathway hsa04657 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Degree 12 Degree centrality 1.29E-03 Betweenness centrality 7.52E-05
Closeness centrality 2.03E-01 Radiality 1.35E+01 Clustering coefficient 6.52E-01
Neighborhood connectivity 1.29E+01 Topological coefficient 3.13E-01 Eccentricity 13
Download Click to Download the Full PPI Network of This Target

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