Target Information
Target General Information | Top | |||||
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Target ID |
T16761
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Target Name |
Pneumocystis carinii Dihydropteroate synthase (PC DHPS)
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Synonyms |
PC DHPS
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Gene Name |
PC DHPS
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Target Type |
Successful target
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[1] | ||||
Disease | [+] 1 Target-related Diseases | + | ||||
1 | Pneumonia [ICD-11: CA40] | |||||
Function |
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
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UniProt ID | ||||||
EC Number |
EC 2.5.1.15
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Sequence |
SFRSYKAPTYIMAILNLTPDSFFDGGIHSYDSVLIDVEKFINAGATIIDIGGQSTRPGSY
IIPLEEEIFRVIPAIKYLQKTYPDILISIDTFRSEVAEQAVKAGASLVNDISGGRYDPKM FNTVARLKVPICIMHMRGNFLNMDNLTDYGTDIIEQITIELEKLLNSAEKSGIPRWNIIL DPGLGFSKTLHQNIELLRRFNELKSKNCFNGLPWLLGPSRKRFTGFITGDNMPKDRIWGT VAAVVASISGGCDIIRVHDVYEMYKISKMSDAIWKEIY Click to Show/Hide
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Drugs and Modes of Action | Top | |||||
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Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
1 | Dapsone | Drug Info | Approved | Pneumocystis pneumonia | [2] | |
Mode of Action | [+] 1 Modes of Action | + | ||||
Modulator | [+] 1 Modulator drugs | + | ||||
1 | Dapsone | Drug Info | [1] |
Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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Co-Targets | Top | |||||
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Co-Targets |
References | Top | |||||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||||
REF 2 | The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. |
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