Target Information
| Target General Information | Top | |||||
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| Target ID |
T30578
(Former ID: TTDS00383)
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| Target Name |
Mycobacterium Arabinosyltransferase C (MycB embC)
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| Synonyms |
Probable arabinosyltransferase C
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| Gene Name |
MycB embC
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| Target Type |
Successful target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Tuberculosis [ICD-11: 1B10-1B12] | |||||
| Function |
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
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| UniProt ID | ||||||
| EC Number |
EC 2.4.2.-
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| Sequence |
MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLN
WPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRG LLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHP GAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVAL TGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTM ARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVIS REVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATS RLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAA TVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLAL VLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSL GALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWS LTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEV VSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAG LSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLP YNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQW ATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIAL TPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEA NSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTV TRSGLWSPAPLRRG Click to Show/Hide
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| Drugs and Modes of Action | Top | |||||
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| Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
| 1 | Ethambutol | Drug Info | Approved | Pulmonary tuberculosis | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 1 Inhibitor drugs | + | ||||
| 1 | Ethambutol | Drug Info | [1] | |||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Octyl Alpha-D-Arabinofuranoside | Ligand Info | |||||
| Structure Description | Crystal structure of the C-terminal extracellular domain of Mycobacterium tuberculosis EmbC | PDB:3PTY | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [3] |
| PDB Sequence |
SVGRSNLQAL
744 AGKTCGLAED754 VLVELDPNAG764 MLAPVTAPLA774 DALGAGLSEA784 FTPNGIPADV 794 GTTAAPGING834 SRARLPYNLD844 PARTPVLGSW854 RAGVQVPAML864 RSGWYRLPTN 874 EQRDRAPLLV884 VTAAGRFDSR894 EVRLQWATDE904 QAAAGHHGGS914 MEFADVGAAP 924 AWRNLRAPLS934 AIPSTATQVR944 LVADDQDLAP954 QHWIALTPPR964 IPRVRTLQNV 974 VGAADPVFLD984 WLVGLAFPCQ994 RPFGHQYGVD1004 ETPKWRILPD1014 RITELLMRAT 1043 TVASYLKDDW1053 FRDWGALQRL1063 TPYY
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Target-Related Models and Studies | Top | |||||
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| Target Validation | ||||||
| References | Top | |||||
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| REF 1 | The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2009 Oct;53(10):4138-46. | |||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 3 | The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module. PLoS Pathog. 2011 Feb;7(2):e1001299. | |||||
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