Target Information

Target General Information

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Target ID

T53578 (Former ID: TTDR00303)

Target Name

Bacterial NADH-dependent enoyl-ACP reductase 1 (Bact fabI1)

Synonyms

NADH-dependent enoyl-ACP reductase 1; Enoyl-[acyl-carrier-protein] reductase [NADH] 1

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Gene Name

Bact fabI1

Target Type

Literature-reported target

[1]

Function

A key enzyme of the type II fatty acid synthesis (FAS) system. Essential for bacterial metabolism and its sequence conservation across many bacterial species but distinctly different from those of mammalian fatty acid biosynthesis enzymes.

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BioChemical Class

CH-CH donor oxidoreductase

UniProt ID

FABI1_RHIME

Sequence

MAQASGLMNGKRGVIMGVANNRSIAWGIAKALAEAGAEIALTWQGDALKKRVEPLAQELG
AFMAGHCDVTDLATIDAVFSALEEKWGKIDFVVHAIAFSDKDELTGRYLDTSRDNFARTM
DISVYSFTAVAARADRVMNDGGSILTLTYYGAEKVMPHYNVMGVAKAALEASVRYLAVDL
GNRGIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLKRTVSIEEVGNSALYLLSDLS
SGVTGEVHHVDSGYHTVGMKAVDAPDISVLKD

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Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

Protein Name	Pfam ID	Percentage of Identity (%)	E value
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (HPGD)	PF00106	22.979 (54/235)	8.24E-06
Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2)	PF00106	27.358 (29/106)	3.00E-03
Dehydrogenase/reductase SDR family member 11 (DHRS11)	PF00106	22.768 (51/224)	3.00E-03
Dehydrogenase/reductase SDR family member 1 (DHRS1)	PF00106	23.469 (46/196)	5.00E-03

Target Affiliated Biological Pathways

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KEGG Pathway

[+] 4 KEGG Pathways

Fatty acid biosynthesis

Biotin metabolism

Metabolic pathways

Fatty acid metabolism

References

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REF 1

Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.

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