Target Information
| Target General Information | Top | |||||
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| Target ID |
T64137
(Former ID: TTDR00387)
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| Target Name |
Corticoliberin (CRH)
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| Synonyms |
Corticotropin-releasing hormone; Corticotropin-releasing factor; Corticotropin releasing hormone; Corticotropin; CRF; Adrenocorticotropic hormone
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| Gene Name |
CRH
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. Hormone regulating the release of corticotropin from pituitary gland.
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| UniProt ID | ||||||
| Sequence |
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQ
ARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLL LPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQL AQQAHSNRKLMEIIGK Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
| HIT2.0 ID | T05WWN | |||||
| Target Regulators | Top | |||||
|---|---|---|---|---|---|---|
| Target-regulating Transcription Factors | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 2 KEGG Pathways | + | ||||
| 1 | Long-term depression | |||||
| 2 | Alcoholism | |||||
| Panther Pathway | [+] 1 Panther Pathways | + | ||||
| 1 | Cortocotropin releasing factor receptor signaling pathway | |||||
| PID Pathway | [+] 1 PID Pathways | + | ||||
| 1 | Rapid glucocorticoid signaling | |||||
| Reactome | [+] 2 Reactome Pathways | + | ||||
| 1 | Class B/2 (Secretin family receptors) | |||||
| 2 | G alpha (s) signalling events | |||||
| WikiPathways | [+] 4 WikiPathways | + | ||||
| 1 | Myometrial Relaxation and Contraction Pathways | |||||
| 2 | Corticotropin-releasing hormone | |||||
| 3 | GPCR ligand binding | |||||
| 4 | GPCR downstream signaling | |||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||||
| REF 2 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
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