Target Information
| Target General Information | Top | |||||
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| Target ID |
T67046
(Former ID: TTDR00161)
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| Target Name |
Platelet activating factor (PAF)
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| Synonyms |
PAF
Click to Show/Hide
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| Gene Name |
NO-GeName
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| Target Type |
Literature-reported target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Fungal infection [ICD-11: 1F29-1F2F] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Preclinical Drug(s) | [+] 1 Preclinical Drugs | + | ||||
| 1 | Indol-3-carbinol | Drug Info | Preclinical | Fungal infection | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 5 Inhibitor drugs | + | ||||
| 1 | Indol-3-carbinol | Drug Info | [1] | |||
| 2 | F-0401 | Drug Info | [3] | |||
| 3 | SRI 63-441 | Drug Info | [4] | |||
| 4 | UR-12670 | Drug Info | [5] | |||
| 5 | SCH 44643 | Drug Info | [6] | |||
| Drug Property Profile of Target | Top | |
|---|---|---|
| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. Planta Med. 1999 Feb;65(1):39-42. | |||||
| REF 2 | Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. | |||||
| REF 3 | Protective effects of a novel calcium antagonist with platelet-activating factor-antagonistic action, F-0401, against ischemic brain damage. Arch Int Pharmacodyn Ther. 1994 May-Jun;327(3):266-78. | |||||
| REF 4 | Pharmacologic modulation of experimental postischemic hepatic function. Ann Surg. 1989 Feb;209(2):200-10. | |||||
| REF 5 | Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. Kidney Int. 1999 Nov;56(5):1798-808. | |||||
| REF 6 | Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys. J Pharm Biomed Anal. 1996 Dec;15(3):343-7. | |||||
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