Target Information
| Target General Information | Top | |||||
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| Target ID |
T70508
(Former ID: TTDNC00434)
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| Target Name |
Cyclin-dependent kinase (CDK)
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| Synonyms |
Cyclin dependent kinase
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| Gene Name |
NO-GeName
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| Target Type |
Clinical trial target
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[1] | ||||
| Disease | [+] 5 Target-related Diseases | + | ||||
| 1 | Acute myeloid leukaemia [ICD-11: 2A60] | |||||
| 2 | Lung cancer [ICD-11: 2C25] | |||||
| 3 | Brain cancer [ICD-11: 2A00] | |||||
| 4 | Breast cancer [ICD-11: 2C60-2C6Y] | |||||
| 5 | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 4 Clinical Trial Drugs | + | ||||
| 1 | Flavopiridol | Drug Info | Phase 2 | Acute myeloid leukaemia | [2], [3] | |
| 2 | R-roscovitine | Drug Info | Phase 2 | Non-small-cell lung cancer | [4], [5] | |
| 3 | TG02 | Drug Info | Phase 1/2 | Anaplastic astrocytoma | [3], [6] | |
| 4 | PF-06873600 | Drug Info | Phase 1 | Breast cancer | [3] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 9 Inhibitor drugs | + | ||||
| 1 | Flavopiridol | Drug Info | [7] | |||
| 2 | R-roscovitine | Drug Info | [1], [8] | |||
| 3 | TG02 | Drug Info | [3] | |||
| 4 | PF-06873600 | Drug Info | [3] | |||
| 5 | Indole-based analog 12 | Drug Info | [9] | |||
| 6 | PMID26161698-Compound-10 | Drug Info | [9] | |||
| 7 | PMID26161698-Compound-44 | Drug Info | [9] | |||
| 8 | Purine derivative 4 | Drug Info | [9] | |||
| 9 | BS-194 | Drug Info | [10] | |||
| Chemical Structure based Activity Landscape of Target | Top |
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| Drug Property Profile of Target | Top | |
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| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| Co-Targets | Top | |||||
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| Co-Targets | ||||||
| References | Top | |||||
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| REF 1 | Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.Clin Cancer Res. 2009 Jun 1;15(11):3716-24. | |||||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6035). | |||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010117) | |||||
| REF 6 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
| REF 7 | Pharma & Vaccines. Product Development Pipeline. April 29 2009. | |||||
| REF 8 | Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer.Clin Cancer Res. 2009 Feb 15;15(4):1435-42. | |||||
| REF 9 | Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. | |||||
| REF 10 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8176). | |||||
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