Target Information
| Target General Information | Top | |||||
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| Target ID |
T72881
(Former ID: TTDR00232)
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| Target Name |
Leukotriene C4 synthase (LTC4S)
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| Synonyms |
Leukotriene-C(4)Leukotriene C4 synthase synthase; Leukotriene-C(4) synthase; LTC4 synthase
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| Gene Name |
LTC4S
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| Target Type |
Patented-recorded target
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[1] | ||||
| Function |
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
Click to Show/Hide
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| BioChemical Class |
Carbon-sulfur lyase
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| UniProt ID | ||||||
| EC Number |
EC 4.4.1.20
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| Sequence |
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA LAALGLLAHFLPAALRAALLGRLRTLLPWA Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| HIT2.0 ID | T42P8F | |||||
| Chemical Structure based Activity Landscape of Target | Top |
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| Drug Property Profile of Target | Top | |
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| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| Target Regulators | Top | |||||
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| Target-regulating Transcription Factors | ||||||
| Target-interacting Proteins | ||||||
| References | Top | |||||
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| REF 1 | Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype. Allergy Asthma Proc. 1999 Nov-Dec;20(6):353-60. | |||||
| REF 2 | COMPOUNDS AND USES. US20160326143. | |||||
| REF 3 | Compounds and uses. US9657001. | |||||
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