Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T74654
(Former ID: TTDS00527)
|
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| Target Name |
Adrenergic neuron (AD neuro)
|
|||||
| Gene Name |
NO-GeName
|
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| Target Type |
Successful target
|
[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Essential hypertension [ICD-11: BA00] | |||||
| 2 | Hypertension [ICD-11: BA00-BA04] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 2 Approved Drugs | + | ||||
| 1 | Debrisoquin | Drug Info | Approved | Hypertension | [2] | |
| 2 | Guanethidine | Drug Info | Approved | Moderate and severe hypertension | [3] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Blocker | [+] 2 Blocker drugs | + | ||||
| 1 | Debrisoquin | Drug Info | [4] | |||
| 2 | Guanethidine | Drug Info | [1], [5] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Characterization of bradykinin-induced endothelium-independent contraction in equine basilar artery. J Vet Pharmacol Ther. 2009 Jun;32(3):264-70. | |||||
| REF 2 | Drug information of Debrisoquin, 2008. eduDrugs. | |||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 4 | Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest. 1970 Aug;49(8):1596-604. | |||||
| REF 5 | Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the... J Pharmacol Exp Ther. 2009 Sep;330(3):745-55. | |||||
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