Target Information

Target General Information

Target ID

T77061 (Former ID: TTDI03161)

Target Name

Doublecortin-like kinase 3 (DCLK3)

Synonyms

Serine/threonine-protein kinase DCLK3; KIAA1765; Doublecortin-like and CAM kinase-like 3; Doublecortin domain-containing protein 3C; DCDC3C; DCAMKL3

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Gene Name

DCLK3

Target Type

Literature-reported target

[1]

Function

Protein kinase activity, peptidyl-serine phosphorylation.

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BioChemical Class

Kinase

UniProt ID

DCLK3_HUMAN

EC Number

EC 2.7.11.1

Sequence

MGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKGDHRCGETETP
KSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSKPPREATLEERHAR
GEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRT
RSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAA
KAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKE
KKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGR
VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEV
YETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKP
ENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAG
VILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKK
RYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS

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3D Structure

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AlphaFold

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Titin (TTN)		32.707 (87/266)	1.02E-36
Testis-specific kinase 1 (TESK1)	PF07714	28.780 (59/205)	3.09E-22
Testis-specific kinase 2 (TESK2)	PF07714	29.947 (56/187)	3.89E-22
LIM domain kinase-1 (LIMK-1)	PF00412 ; PF00595 ; PF07714 More >>	27.305 (77/282)	2.79E-21
TGF-beta-activated kinase 1 (MAP3K7)	PF07714	28.464 (76/267)	2.81E-21
LIM domain kinase-2 (LIMK-2)	PF00412 ; PF00595 ; PF07714 More >>	27.404 (57/208)	1.88E-20
Tyrosine-protein kinase BMX (BMX)	PF00779 ; PF00169 ; PF07714 ; PF00017 More >>	27.273 (69/253)	2.18E-18
Proto-oncogene c-Fes (FES)	PF07714 ; PF00017	29.688 (57/192)	6.18E-18
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)	PF07714	24.800 (62/250)	6.49E-18
Tyrosine-protein kinase ABL2 (ABL2)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	25.346 (55/217)	1.20E-17
Mixed lineage kinase 3 (MAP3K11)	PF07714 ; PF14604	28.571 (58/203)	1.72E-17
Tyrosine-protein kinase ABL1 (ABL)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	25.701 (55/214)	1.81E-17
Mixed lineage kinase 2 (MAP3K10)	PF07714 ; PF14604	27.094 (55/203)	5.57E-17
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)	PF07714	24.800 (62/250)	1.27E-16
Tyrosine-protein kinase Tec (PSCTK4)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	25.561 (57/223)	4.86E-16
Tyrosine-protein kinase BTK (ATK)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	28.723 (54/188)	5.45E-16
T-cell-specific kinase (ITK)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	27.660 (52/188)	6.14E-16
Janus kinase 2 (JAK-2)	PF18379 ; PF18377 ; PF17887 ; PF07714 ; PF00017 More >>	30.131 (69/229)	9.52E-16
Focal adhesion kinase 1 (FAK)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	26.667 (68/255)	3.00E-15
Tyrosine-protein kinase BRK (PTK6)	PF07714 ; PF00017 ; PF00018 More >>	26.582 (63/237)	4.12E-15
Proto-oncogene c-Fer (FER)	PF00611 ; PF07714 ; PF00017 More >>	26.577 (59/222)	1.31E-14
Mixed lineage kinase 4 (MAP3K21)	PF07714 ; PF14604	26.991 (61/226)	2.37E-14
Proto-oncogene c-Ros (ROS1)	PF00041 ; PF07714	26.506 (66/249)	1.78E-13
Proto-oncogene c-RAF (c-RAF)	PF00130 ; PF07714 ; PF02196 More >>	22.569 (65/288)	2.90E-13
Janus kinase 3 (JAK-3)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	30.233 (65/215)	3.51E-13
Receptor-interacting protein 1 (RIPK1)	PF00531 ; PF07714 ; PF12721 More >>	25.333 (57/225)	4.14E-13
TYK2 tyrosine kinase (TYK2)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	31.694 (58/183)	5.72E-13
Proto-oncogene c-Ret (RET)	PF00028 ; PF07714 ; PF17756 ; PF17812 ; PF17813 More >>	28.070 (80/285)	7.57E-13
Tyrosine-protein kinase Srms (SRMS)	PF07714 ; PF00017	25.641 (50/195)	8.17E-13
Serine/threonine-protein kinase B-raf (BRAF)	PF00130 ; PF07714 ; PF02196 More >>	24.336 (55/226)	1.03E-12
Tyrosine-protein kinase TXK (TXK)	PF07714 ; PF00017 ; PF00018 More >>	25.366 (52/205)	1.06E-12
Tyrosine-protein kinase Lyn (JTK8)	PF07714 ; PF00017 ; PF00018 More >>	27.586 (48/174)	1.28E-12
Hematopoietic cell kinase (HCK)	PF07714 ; PF00017 ; PF00018 More >>	29.341 (49/167)	1.79E-12
Macrophage-stimulating protein receptor (RON)	PF07714 ; PF01403 ; PF01833 More >>	26.667 (64/240)	2.30E-12
TYRO3 tyrosine kinase receptor (TYRO3)	PF00041 ; PF07679 ; PF07714 More >>	23.162 (63/272)	2.83E-12
Ephrin type-B receptor 4 (EPHB4)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	25.253 (50/198)	3.93E-12
Focal adhesion kinase 2 (PTK2B)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	27.885 (58/208)	4.31E-12
Fibroblast growth factor receptor 1 (FGFR1)	PF07679 ; PF00047 ; PF07714 More >>	28.571 (70/245)	7.86E-12
Serine/threonine-protein kinase A-Raf (ARAF)	PF00130 ; PF07714 ; PF02196 More >>	25.000 (61/244)	9.75E-12
Tyrosine-protein kinase CSK (CSK)	PF07714 ; PF00017 ; PF00018 More >>	27.966 (66/236)	1.22E-11
Tyrosine-protein kinase UFO (AXL)	PF00041 ; PF13927 ; PF07714 More >>	24.088 (66/274)	1.33E-11
ALK tyrosine kinase receptor (ALK)	PF12810 ; PF00629 ; PF07714 More >>	25.275 (46/182)	2.58E-11
Angiopoietin 1 receptor (TEK)	PF00041 ; PF10430 ; PF07714 More >>	29.167 (63/216)	3.82E-11
MLK-related kinase (MLTK)	PF07714 ; PF00536	25.743 (52/202)	4.26E-11
Ephrin type-A receptor 7 (EPHA7)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	25.000 (49/196)	4.75E-11
Fibroblast growth factor receptor 2 (FGFR2)	PF07679 ; PF13927 ; PF07714 More >>	26.230 (64/244)	4.82E-11
Janus kinase 1 (JAK-1)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	29.185 (68/233)	5.32E-11
Fibroblast growth factor receptor 3 (FGFR3)	PF07679 ; PF13927 ; PF07714 More >>	25.926 (63/243)	6.13E-11
LCK tyrosine protein kinase (LCK)	PF07714 ; PF00017 ; PF00018 More >>	26.857 (47/175)	6.71E-11
Megakaryocyte-associated tyrosine-protein kinase (MATK)	PF07714 ; PF00017 ; PF00018 More >>	25.339 (56/221)	6.86E-11
Serine/threonine-protein kinase TNNI3K (TNNI3K)	PF12796 ; PF13637 ; PF07714 More >>	25.592 (54/211)	9.92E-11
Non-receptor tyrosine-protein kinase TNK1 (TNK1)	PF07714	26.217 (70/267)	1.04E-10
Ephrin type-A receptor 1 (EPHA1)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	26.638 (61/229)	1.65E-10
Ephrin type-A receptor 8 (EPHA8)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	26.141 (63/241)	2.93E-10
Tyrosine-protein kinase Mer (MERTK)	PF00041 ; PF00047 ; PF07714 More >>	24.576 (58/236)	3.98E-10
Tyrosine-protein kinase FRK (FRK)	PF07714 ; PF00017 ; PF00018 More >>	24.155 (50/207)	4.00E-10
Fibroblast growth factor receptor 4 (FGFR4)	PF07679 ; PF13927 ; PF07714 More >>	26.587 (67/252)	4.13E-10
Ephrin type-B receptor 1 (EPHB1)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	25.381 (50/197)	4.17E-10
Ephrin type-A receptor 4 (EPHA4)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF07647 More >>	25.510 (50/196)	4.21E-10
Tyrosine-protein kinase ZAP-70 (ZAP-70)	PF07714 ; PF00017	25.907 (50/193)	6.40E-10
Renal carcinoma antigen NY-REN-64 (IRAK-4)	PF07714	27.184 (56/206)	7.13E-10
Muscle-specific kinase receptor (MUSK)	PF01392 ; PF07679 ; PF13927 ; PF07714 More >>	24.535 (66/269)	7.20E-10
B lymphocyte kinase (BLK)	PF07714 ; PF00017 ; PF00018 More >>	24.737 (47/190)	9.72E-10
Proto-oncogene c-Met (MET)	PF07714 ; PF01437 ; PF01403 ; PF01833 More >>	26.214 (54/206)	1.11E-09
Ephrin type-A receptor 3 (EPHA3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF07647 More >>	22.959 (45/196)	1.38E-09
Proto-oncogene c-Src (SRC)	PF07714 ; PF00017 ; PF00018 More >>	28.378 (42/148)	1.42E-09
Neurotrophic tyrosine kinase ROR2 (ROR2)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	25.500 (51/200)	1.69E-09
Ephrin type-B receptor 2 (EPHB2)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	25.325 (39/154)	1.73E-09
Ephrin type-A receptor 5 (EPHA5)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	23.980 (47/196)	3.57E-09
Dual serine/threonine and tyrosine protein kinase (DSTYK)	PF07714	25.893 (58/224)	3.70E-09
Tie-1 tyrosine kinase receptor (TIE1)	PF00041 ; PF00047 ; PF07714 More >>	25.926 (56/216)	3.79E-09
Serine/threonine-protein kinase LMTK3 (LMTK3)	PF07714	25.283 (67/265)	4.29E-09
BDNF/NT-3 growth factors receptor (TrkB)	PF07679 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	24.057 (51/212)	4.86E-09
Ephrin type-B receptor 3 (EPHB3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	24.242 (48/198)	4.93E-09
Ephrin type-A receptor 2 (EPHA2)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	23.980 (47/196)	4.94E-09
Leukocyte receptor tyrosine kinase (LTK)	PF12810 ; PF07714	24.409 (62/254)	5.40E-09
Fyn tyrosine protein kinase (FYN)	PF07714 ; PF00017 ; PF00018 More >>	27.027 (40/148)	6.16E-09
Epithelial discoidin domain receptor 1 (DDR1)	PF00754 ; PF07714	24.365 (48/197)	1.26E-08
Discoidin domain-containing receptor 2 (DDR2)	PF00754 ; PF07714	25.140 (45/179)	1.60E-08
Insulin receptor (INSR)	PF00757 ; PF17870 ; PF07714 ; PF01030 More >>	22.794 (62/272)	1.75E-08
Tyrosine-protein kinase Fgr (FGR)	PF07714 ; PF00017 ; PF00018 More >>	25.668 (48/187)	1.82E-08
Yes tyrosine kinase (YES)	PF07714 ; PF00017 ; PF00018 More >>	28.667 (43/150)	2.42E-08
Bone morphogenetic protein receptor type-1B (BMPR1B)	PF01064 ; PF07714 ; PF08515 More >>	29.787 (42/141)	7.76E-08
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1)	PF12796 ; PF13637 ; PF07714 More >>	23.019 (61/265)	1.29E-07
Tropomyosin-related kinase A (TrkA)	PF13855 ; PF16920 ; PF07714 ; PF18613 More >>	21.698 (46/212)	2.40E-07
Inactive tyrosine-protein kinase 7 (PTK7)	PF07679 ; PF13927 ; PF07714 More >>	25.641 (40/156)	3.18E-07
Activated CDC42 kinase 1 (ACK-1)	PF09027 ; PF11555 ; PF07714 ; PF14604 More >>	25.000 (51/204)	3.30E-07
Fms-like tyrosine kinase 3 (FLT-3)	PF00047 ; PF07714	29.323 (39/133)	3.52E-07
NT-3 growth factor receptor (TrkC)	PF07679 ; PF00047 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	21.834 (50/229)	4.23E-07
Vascular endothelial growth factor receptor 1 (FLT-1)	PF07679 ; PF00047 ; PF13927 ; PF07714 ; PF17988 More >>	27.523 (30/109)	8.66E-07
Activin receptor-like kinase 2 (ALK-2)	PF01064 ; PF07714 ; PF08515 More >>	26.437 (46/174)	1.13E-06
Tyrosine-protein kinase SYK (SYK)	PF07714 ; PF00017	21.078 (43/204)	1.63E-06
Erbb4 tyrosine kinase receptor (Erbb-4)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	23.950 (57/238)	1.92E-06
Bone morphogenetic protein receptor type-1A (BMPR1A)	PF01064 ; PF07714 ; PF08515 More >>	29.286 (41/140)	1.96E-06
Insulin receptor-related protein (INSRR)	PF00757 ; PF07714 ; PF01030 More >>	23.558 (49/208)	2.02E-06
Erbb3 tyrosine kinase receptor (Erbb-3)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	23.116 (46/199)	2.19E-06
Tyrosine-protein kinase Kit (KIT)	PF00047 ; PF07714	27.097 (42/155)	2.92E-06
Epidermal growth factor receptor (EGFR)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	22.881 (54/236)	3.50E-06
Neurotrophic tyrosine kinase ROR1 (ROR1)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	20.339 (36/177)	5.53E-06
Vascular endothelial growth factor receptor 3 (FLT-4)	PF07679 ; PF13927 ; PF07714 ; PF17988 More >>	27.103 (29/107)	5.91E-06
Platelet-derived growth factor receptor beta (PDGFRB)	PF07679 ; PF00047 ; PF13927 ; PF07714 More >>	27.966 (33/118)	8.43E-06
Activin receptor-like kinase-1 (ACVRL1)	PF07714 ; PF08515	28.161 (49/174)	1.13E-05
Tyrosine-protein kinase STYK1 (STYK1)	PF07714	27.160 (44/162)	1.45E-05
Vascular endothelial growth factor receptor 2 (KDR)	PF07679 ; PF13927 ; PF07714 ; PF17988 More >>	25.688 (28/109)	1.48E-05
Ephrin type-B receptor 6 (EPHB6)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF07647 More >>	19.626 (42/214)	1.80E-05
TGF-beta receptor type II (TGFBR2)	PF08917 ; PF07714	26.906 (60/223)	2.13E-05
Platelet-derived growth factor receptor alpha (PDGFRA)	PF07679 ; PF07714	23.973 (35/146)	2.40E-05
Serine/threonine-protein kinase LMTK1 (AATK)	PF07714	25.000 (41/164)	2.48E-05
Ephrin type-A receptor 6 (EPHA6)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	23.810 (30/126)	2.97E-05
Insulin-like growth factor I receptor (IGF1R)	PF00757 ; PF07714 ; PF01030 More >>	21.898 (60/274)	3.76E-05
Activin receptor type-1C (ACVR1C)	PF01064 ; PF07714 ; PF08515 More >>	28.000 (42/150)	4.93E-05
Kinase suppressor of Ras 2 (KSR2)	PF07714 ; PF13543 ; PF20406 More >>	22.271 (51/229)	5.44E-05
Guanylyl cyclase C (GUCY2C)	PF00211 ; PF07714	23.776 (34/143)	8.68E-05
Erbb2 tyrosine kinase receptor (HER2)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	22.553 (53/235)	8.92E-05
Macrophage colony-stimulating factor 1 receptor (CSF1R)	PF00047 ; PF13927 ; PF07714 More >>	25.253 (25/99)	1.74E-04
Ephrin type-A receptor 10 (EPHA10)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	22.165 (43/194)	3.03E-04
Retinal guanylyl cyclase 2 (GUCY2F)	PF01094 ; PF00211 ; PF07701 ; PF07714 More >>	23.529 (40/170)	2.00E-03
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	PF00619 ; PF07714	23.567 (37/157)	3.00E-03
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References

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REF 1

URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2007).

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