Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Cell-based Target Expression Variations
References
Drug Binding Sites of Target  Top
Ligand Name: Flavin-Adenine Dinucleotide Ligand Info
Structure Description Crystal Structure Analysis of Trypanosoma cruzi Lipoamide dehydrogenase PDB:2QAE
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [2]
PDB Sequence
NPYDVVVIGG
10
GPGGYVASIK
20
AAQLGMKTAC
30
VEKRGALGGT
40
CLNVGCIPSK
50

ALLHATHLYH
60
DAHANFARYG
70
LMGGEGVTMD
80
SAKMQQQKER
90
AVKGLTGGVE
100

YLFKKNKVTY
110
YKGEGSFETA
120
HSIRVNGLDG
130
KQEMLETKKT
140
IIATGSEPTE
150

LPFLPFDEKV
160
VLSSTGALAL
170
PRVPKTMVVI
180
GGGVIGLELG
190
SVWARLGAEV
200

TVVEFAPRCA
210
PTLDEDVTNA
220
LVGALAKNEK
230
MKFMTSTKVV
240
GGTNNGDSVS
250

LEVEGKRETV
263
TCEALLVSVG
273
RRPFTGGLGL
283
DKINVAKNER
293
GFVKIGDHFE
303

TSIPDVYAIG
313
DVVDKGPMLA
323
HKAEDEGVAC
333
AEILAGKPGH
343
VNYGVIPAVI
353

YTMPEVASVG
363
KSEDELKKEG
373
VAYKVGKFPF
383
NANSRAKAVS
393
TEDGFVKVLV
403

DKATDRILGV
413
HIVCTTAGEL
423
IGEACLAMEY
433
GASSEDVGRT
443
CHAHPTMSEA
453

LKEACMALFA
463
KTINF
Residue
Distance (Å)
ILE8
3.517
GLY9
3.674
GLY10
4.308
GLY11
3.394
PRO12
3.300
GLY13
2.975
GLY14
4.216
VAL31
3.565
GLU32
2.580
LYS33
3.325
ARG34
2.967
GLY38
4.424
GLY39
3.257
THR40
2.685
CYS41
3.507
VAL44
3.796
GLY45
3.264
CYS46
3.329
SER49
3.840
LYS50
2.845
GLY113
3.406
GLU114
3.563
GLY115
2.924
ALA143
3.793
Residue
Distance (Å)
THR144
3.384
GLY145
3.325
SER146
3.825
SER164
3.619
LEU168
4.268
ILE185
3.681
GLU188
4.808
LEU189
4.450
ARG274
3.445
PHE277
3.553
GLY279
4.303
GLY280
4.844
LEU281
3.985
ILE312
4.501
GLY313
3.431
ASP314
2.895
VAL315
4.737
MET321
3.186
LEU322
2.886
ALA323
2.922
HIS324
3.334
ALA326
3.943
TYR354
3.756
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
Protein Name Pfam ID Percentage of Identity (%) E value
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2)
PF01593 ; 
PF13450
37.500 (21/56) 3.00E-03

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