Target Information
Target General Information | Top | |||||
---|---|---|---|---|---|---|
Target ID |
T84591
|
|||||
Target Name |
Guanine nucleotide exchange factor (GNEF)
|
|||||
Synonyms |
eIF-2B GDP-GTP exchange factor; Translation initiation factor eIF-2B; EIF2B
Click to Show/Hide
|
|||||
Gene Name |
EIF2B1; EIF2B2
|
|||||
Target Type |
Clinical trial target
|
[1] | ||||
Disease | [+] 1 Target-related Diseases | + | ||||
1 | Lung cancer [ICD-11: 2C25] | |||||
Function |
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Click to Show/Hide
|
|||||
UniProt ID | ||||||
Sequence |
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD
SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL IKLYL Click to Show/Hide
|
Drugs and Modes of Action | Top | |||||
---|---|---|---|---|---|---|
Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
1 | Plinabulin | Drug Info | Phase 3 | Non-small-cell lung cancer | [1] | |
Mode of Action | [+] 1 Modes of Action | + | ||||
Stimulator | [+] 1 Stimulator drugs | + | ||||
1 | Plinabulin | Drug Info | [1] |
Co-Targets | Top | |||||
---|---|---|---|---|---|---|
Co-Targets |
References | Top | |||||
---|---|---|---|---|---|---|
REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.