Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T03818 | |||||||||||||||||
| Target Name | Peroxisome proliferator-activated receptor gamma (PPARG) | |||||||||||||||||
| Gene Name | PPARG | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | PPARG_HUMAN | |||||||||||||||||
| Sequence |
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETDMSLHPLLQEIYKDLY [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: P465L | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: P467L | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.Diabetes.2010 Nov;59(11):2890-7. | |||||||||||||||||
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