Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T12355 | |||||||||||||||||
| Target Name | G1/S-specific cyclin D1 (CCND1) | |||||||||||||||||
| Gene Name | CCND1 | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | CCND1_HUMAN | |||||||||||||||||
| Sequence |
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI [Hom o sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: C47S | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: T286A | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: Y44D | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.Oncotarget.2016 Nov 8;7(45):73558-73572. | |||||||||||||||||
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