Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T15739 | |||||||||||||||||
| Target Name | Cellular tumor antigen p53 (TP53) | |||||||||||||||||
| Gene Name | TP53 | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | P53_HUMAN | |||||||||||||||||
| Sequence |
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: R175H + R248G | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line. Oncogene. 2000 Oct 19;19(44):5098-105. | |||||||||||||||||
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