| Target General Information |
| Target ID |
T31595
|
| Target Name |
Influenza Neuraminidase (NA) |
| Gene Name |
NA |
| Species |
Influenza A viruses H1N1 |
| UniProt ID |
C3W5Y1_9INFA |
| Sequence |
MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCNQSVITYENNT
WVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREP
FISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWS
ASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFT
VMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN
RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIG
RTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRP
CFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK [Influenza
A viruses H1N1]
|
| Drug and Corresponding Resistance Mutations |
| Mutation Info |
Missense: E119G |
| Drugs |
| Drug Name |
Zanamivir |
Drug Info
|
[1] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Zanamivir |
Drug Info
|
[1] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Peramivir |
Drug Info
|
[1] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Oseltamivir |
Drug Info
|
[1] |
| Targeted Disease |
Influenza virus infection |
|
| Mutation Info |
Missense: H275Y |
| Drugs |
| Drug Name |
Oseltamivir |
Drug Info
|
[3] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Amantadine |
Drug Info
|
[3] |
| Targeted Disease |
Influenza virus infection |
|
| Mutation Info |
Missense: R118P |
| Drugs |
| Drug Name |
Zanamivir |
Drug Info
|
[2] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Zanamivir |
Drug Info
|
[2] |
| Targeted Disease |
Influenza virus infection |
|
| Mutation Info |
Missense: R292K |
| Drugs |
| Drug Name |
Zanamivir |
Drug Info
|
[2] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Zanamivir |
Drug Info
|
[2] |
| Targeted Disease |
Influenza virus infection |
|
| Mutation Info |
Missense: R292W |
| Drugs |
| Drug Name |
Zanamivir |
Drug Info
|
[2] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Zanamivir |
Drug Info
|
[2] |
| Targeted Disease |
Influenza virus infection |
|
| References |
| REF 1 |
Insights into susceptibility of antiviral drugs against the E119G mutant of 2009 influenza A (H1N1) neuraminidase by molecular dynamics simulations and free energy calculations. Antiviral Res. 2013 Nov;100(2):356-64.
|
| REF 2 |
Computational assay of Zanamivir binding affinity with original and mutant influenza neuraminidase 9 using molecular docking. J Theor Biol. 2015 Nov 21;385:31-9.
|
| REF 3 |
Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. Eur J Med Chem. 2017 Jul 28;135:70-76.
|
