Resistance mutation info of target
| Target General Information | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T38257 | ||||||||||||||||||||||
| Target Name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) | ||||||||||||||||||||||
| Gene Name | PTEN | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| UniProt ID | PTEN_HUMAN | ||||||||||||||||||||||
| Sequence |
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | |||||||||||||||||||||||
| Mutation Info | Missense: R159S | ||||||||||||||||||||||
| Drugs |
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| References | |||||||||||||||||||||||
| REF 1 | Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma. J Clin Invest. 2015 Apr;125(4):1459-70. | ||||||||||||||||||||||
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