Target General Information
Target ID	T56556
Target Name	ATP-binding cassette sub-family G member 2 (ABCG2)
Gene Name	ABCG2
Species	Homo sapiens
UniProt ID	ABCG2_HUMAN
Sequence	MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS [Hom o sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info	Missense: R482*
Drugs	Drug Name Teniposide Drug Info [3] Targeted Disease Cancer
	Drug Name Etoposide Drug Info [3] Targeted Disease Cancer
Mutation Info	Missense: R482G
Drugs	Drug Name Mitoxantrone Drug Info [4] Targeted Disease Breast Cancer
	Drug Name Methotrexate Drug Info [5] Targeted Disease Leukemia; Cancer
Mutation Info	Missense: R482M
Drugs	Drug Name Zidovudine Drug Info [2] Targeted Disease HIV infection
Mutation Info	Missense: R482T
Drugs	Drug Name Anthracycline Drug Info [1] Targeted Disease Cancer
	Drug Name SN-38 Drug Info [1] Targeted Disease Cancer
	Drug Name Anthracycline Drug Info [1] Targeted Disease T-lineage acute lymphoblastic leukaemia
	Drug Name Topotecan Drug Info [1] Targeted Disease Cancer
References
REF 1	Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. Cancer Res. 2001 Sep 15;61(18):6635-9.
REF 2	Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein. Biochem Pharmacol. 2004 Oct 1;68(7):1363-70.
REF 3	Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primar... Cancer Res. 2003 Mar 15;63(6):1339-44.
REF 4	Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Biochem J. 2004 Sep 1;382(Pt 2):711-6.
REF 5	Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance prote... Biochem J. 2005 Jan 15;385(Pt 2):419-26.

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