Target General Information
Target ID T58454
Target Name Fibroblast growth factor receptor 2 (FGFR2)
Gene Name FGFR2
Species Homo sapiens
UniProt ID FGFR2_HUMAN
Sequence MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: E566G
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
Mutation Info Missense: I548V
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
Mutation Info Missense: K660E
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
Mutation Info Missense: L618M
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
Mutation Info Missense: M536I
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
Mutation Info Missense: M538I
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
Mutation Info Missense: V565I
Drugs
Drug Name Dovitinib Drug Info [1]
Targeted Disease Endometrium Cancer
References
REF 1 The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors. Neoplasia. 2013 Aug;15(8):975-88.

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