| Target General Information |
| Target ID |
T72657
|
| Target Name |
Bacterial 30S ribosomal protein S12 (rpsL) |
| Gene Name |
rpsL |
| Species |
Mycobacterium tuberculosis |
| UniProt ID |
RS12_MYCTU |
| Sequence |
MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQ
VEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAK
KEKG [Mycobacterium tuberculosis]
|
| Drug and Corresponding Resistance Mutations |
| Mutation Info |
Missense: G84V |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K43R |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[2], [3] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K43T |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[5] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
5 out of 15 isolates |
|
| Mutation Info |
Missense: K51N |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K88M |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[7] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
10 out of 17 isolates |
|
| Mutation Info |
Missense: K88Q |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[2], [4] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
9 out of 139 isolates |
|
| Mutation Info |
Missense: K88R |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[2], [5] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
2 out of 15 isolates |
|
| Mutation Info |
Missense: K88T |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[7] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
10 out of 17 isolates |
|
| Mutation Info |
Missense: R86P |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[6] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: R86W |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: R9H |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[4] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 139 isolates |
|
| Mutation Info |
Missense: T40I |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1], [2] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: T41S |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V52G |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V87L |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V93M |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info
|
[4] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 139 isolates |
|
| References |
| REF 1 |
Molecular characterisation of streptomycin-resistant Mycobacterium tuberculosis strains isolated in Poland. Int J Tuberc Lung Dis. 2004 Aug;8(8):1032-5.
|
| REF 2 |
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
|
| REF 3 |
The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis. Mol Microbiol. 1993 Nov;10(3):521-7.
|
| REF 4 |
Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities. Antimicrob Agents Chemother. 1996 Apr;40(4):1024-6.
|
| REF 5 |
Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot. Mol Microbiol. 1993 Sep;9(6):1239-46.
|
| REF 6 |
Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. Mol Microbiol. 2007 Feb;63(4):1096-106.
|
| REF 7 |
Characterization of the rpsL and rrs genes of streptomycin-resistant clinical isolates of Mycobacterium tuberculosis in Japan. J Appl Microbiol. 1997 Nov;83(5):634-40.
|
