Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T94085 | |||||||||||||||||
| Target Name | Retinoic acid receptor alpha (RARA) | |||||||||||||||||
| Gene Name | RARA | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | RARA_HUMAN | |||||||||||||||||
| Sequence |
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: A216V | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Evaluating frequency of PML-RARA mutations and conferring resistance to arsenic trioxide-based therapy in relapsed acute promyelocytic leukemia patients.Ann Hematol.2015 Nov;94(11):1829-37. | |||||||||||||||||
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