Resistance mutation info of target
| Target General Information | ||||||||||||||||||
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| Target ID | T96311 | |||||||||||||||||
| Target Name | NEDD8-activating enzyme E1 catalytic subunit (UBA3) | |||||||||||||||||
| Gene Name | UBA3 | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | UBA3_HUMAN | |||||||||||||||||
| Sequence |
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: I310N | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: Y352H | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.PLoS One.2014 Apr 1;9(4):e93530. | |||||||||||||||||
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