Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T96760 | |||||||||||||||||
| Target Name | Growth differentiation factor-5 (GDF5) | |||||||||||||||||
| Gene Name | GDF5 | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | GDF5_HUMAN | |||||||||||||||||
| Sequence |
MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID SANNVVYKQYEDMVVESCGCR [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: N445K | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: N445T | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.PLoS Genet.2009 Nov;5(11):e1000747. | |||||||||||||||||
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