Drug Information

Drug General Information
Drug ID
D0CL9S
Former ID
DAP000698
Drug Name
Telbivudine
Synonyms
Epavudine; LLT; LdT; Sebivo; Telbivudin; Tyzeka; Telbivudine [USAN]; LDT600; NB 02B; NV 02B; L-Deoxythymidine; L-Thymidine; L-dT; LDT-600; NV-02B; Tyzeka (TN); Beta-L-Thymidine; Telbivudine (USAN/INN); Tyzake/Sebivo (TN); Tyzeka, Sebivo, Telbivudine; 1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-(2-Deoxy-beta-L-erythropentafuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Deoxy-L-thymidine; LdT
Drug Type
Small molecular drug
Indication HBV infection [ICD9: 070.2-070.3; ICD10:B16, B18.0, B18.1] Approved [536994]
Therapeutic Class
Antiviral Agents
Company
Idenix
Structure
Download
2D MOL

3D MOL
Formula
C10H14N2O5
Canonical SMILES
CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
InChI
1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
InChIKey
IQFYYKKMVGJFEH-CSMHCCOUSA-N
CAS Number
CAS 3424-98-4
PubChem Compound ID
159269
PubChem Substance ID
649439, 866449, 10253548, 12015420, 15220960, 15220961, 46234569, 46508706, 47208326, 50070122, 50070883, 57348574, 79679357, 81044332, 92721242, 99299522, 104234230, 104253286, 113442015, 113585147, 124757407, 125164211, 126619322, 126645820, 126662079, 134224136, 134337987, 135115725, 135611174, 135692211, 135778824, 137005934, 141758313, 152343276, 160657121, 160964596, 172919923, 174007441, 175267960, 176484712, 179150345, 184598259, 210279169, 210281492, 223454562, 223668197, 226495211, 241047041, 241075091, 249582920
SuperDrug ATC ID
J05AF11
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HBV polymerase Target Info Inhibitor [537047]
References
Ref 536994Nucleoside and nucleotide analogs in the treatment of chronic hepatitis B. Enferm Infecc Microbiol Clin. 2008 May;26 Suppl 7:32-8.
Ref 537047Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol. 2008;22(6):1081-92.

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