Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L5LG
|
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| Former ID |
DNC001345
|
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| Drug Name |
SN-38
|
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H20N2O5
|
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| InChIKey |
FJHBVJOVLFPMQE-QFIPXVFZSA-N
|
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| CAS Number |
CAS 86639-52-3
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
13355, 515301, 622834, 10233636, 11430409, 12012598, 14805294, 14805295, 44434437, 49835447, 50028359, 50112971, 56311337, 56311445, 56311571, 56312630, 57337873, 71831605, 80486942, 87559919, 89360249, 92712502, 103220117, 103996165, 104373061, 126588659, 126625532, 126656661, 126666539, 127855413, 134340412, 134340540, 135062353, 135693781, 135710073, 136377612, 136897516, 136911131, 137138435, 142309355, 144115510, 152059852, 152164367, 152200177, 152245349, 162178284, 162223790, 163367112, 164178264, 164194982
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | Toposisomerase-1 | Target Info | Modulator | ||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | DNA replication | ||||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | ||||
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| References | |||||
| Ref 532503 | Randomized phase 2 study of pegylated SN-38 (EZN-2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer. Cancer. 2013 Dec 15;119(24):4223-30. | ||||
| Ref 541970 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6925). | ||||
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