Drug Information

Drug General Information
Drug ID
DX0ESD
Drug Name
(Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylmethylsulfonamido)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid
Synonyms
CHEMBL1215216
Indication Discovery agent Investigative [1587926]
Formula
C27H25N3O6S
Canonical SMILES
OC(=O)CCc1c(\\C=C\\2/C(=O)Nc3ccc(NS(=O)(=O)Cc4ccccc4)cc23)[nH]c5CCCC(=O)c15
InChI
InChI=1S/C27H25N3O6S/c31-24-8-4-7-22-26(24)18(10-12-25(32)33)23(28-22)14-20-19-13-17(9-11-21(19)29-27(20)34)30-37(35,36)15-16-5-2-1-3-6-16/h1-3,5-6,9,11,13-14,28,30H,4,7-8,10,12,15H2,(H,29,34)(H,32,33)/b20-14-
InChIKey
WYLTWMHCCIFULE-ZHZULCJRSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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