Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX0Z5E
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| Drug Name |
7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 2HCl
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| Synonyms |
CHEMBL553331
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C27H32Cl2F2N6O2
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| Canonical SMILES |
Cl.Cl.CN1C(=O)N(C)c2ncn(CCCN3CCN(CC3)C(c4ccc(F)cc4)c5ccc(F)cc5)c2C1=O
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| InChI |
InChI=1S/C27H30F2N6O2.2ClH/c1-31-25-24(26(36)32(2)27(31)37)35(18-30-25)13-3-12-33-14-16-34(17-15-33)23(19-4-8-21(28)9-5-19)20-6-10-22(29)11-7-20;;/h4-11,18,23H,3,12-17H2,1-2H3;2*1H
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| InChIKey |
PNOSOZWRHNNHGW-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Alpha-1 adrenergic receptor | Target Info | [1] | ||
| Histamine H1 receptor | Target Info | [1] | |||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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