Drug Information
| Drug General Information | |||||
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| Drug ID |
DX2J2L
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| Drug Name |
(3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methanesulfonate
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| Synonyms |
CHEMBL500115
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C26H22ClFN4O4S2
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| Canonical SMILES |
CS(=O)(=O)O[C@H]1CN[C@@H](C1)C#Cc2cc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3s2
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| InChI |
InChI=1S/C26H22ClFN4O4S2/c1-38(33,34)36-20-10-18(29-13-20)5-7-21-12-23-25(37-21)26(31-15-30-23)32-19-6-8-24(22(27)11-19)35-14-16-3-2-4-17(28)9-16/h2-4,6,8-9,11-12,15,18,20,29H,10,13-14H2,1H3,(H,30,31,32)/t18-,20-/m1/s1
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| InChIKey |
SHMDVAIGKWZURP-UYAOXDASSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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