Drug General Information |
Drug ID |
DX2LIV
|
Drug Name |
2-((2-cyanopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide
|
Synonyms |
CHEMBL248257
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C21H14F2N4O3
|
Canonical SMILES |
FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc4ccnc(c4)C#N)cc2O1
|
InChI |
InChI=1S/C21H14F2N4O3/c22-21(23)29-18-6-5-14(10-19(18)30-21)27-20(28)16-3-1-2-4-17(16)26-12-13-7-8-25-15(9-13)11-24/h1-10,26H,12H2,(H,27,28)
|
InChIKey |
MBVMUJLUEAVVFH-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Mast/stem cell growth factor receptor |
Target Info |
|
[1]
|
B-Raf proto-oncogene serine/threonine-protein kinase |
Target Info |
|
[1]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
Endocytosis
|
PI3K-Akt signaling pathway
|
Hematopoietic cell lineage
|
Melanogenesis
|
Pathways in cancer
|
Acute myeloid leukemia
|
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
|
ErbB signaling pathway
|
cAMP signaling pathway
|
Chemokine signaling pathway
|
FoxO signaling pathway
|
mTOR signaling pathway
|
Vascular smooth muscle contraction
|
Focal adhesion
|
Natural killer cell mediated cytotoxicity
|
Long-term potentiation
|
Neurotrophin signaling pathway
|
Serotonergic synapse
|
Long-term depression
|
Regulation of actin cytoskeleton
|
Insulin signaling pathway
|
Progesterone-mediated oocyte maturation
|
Alcoholism
|
Hepatitis C
|
Proteoglycans in cancer
|
Colorectal cancer
|
Renal cell carcinoma
|
Pancreatic cancer
|
Endometrial cancer
|
Glioma
|
Prostate cancer
|
Thyroid cancer
|
Melanoma
|
Bladder cancer
|
Chronic myeloid leukemia
|
Non-small cell lung cancer
|
NetPath Pathway
|
IL3 Signaling Pathway
|
IL4 Signaling Pathway
|
KitReceptor Signaling PathwayNetPath_19:IL-7 Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
Integrin signalling pathway
|
Interleukin signaling pathway
|
PDGF signaling pathway
|
T cell activation
|
VEGF signaling pathway
|
Ras Pathway
|
CCKR signaling map ST
|
Pathway Interaction Database
|
C-MYB transcription factor network
|
Signaling events mediated by Stem cell factor receptor (c-Kit)cdc42_pathway:CDC42 signaling events
|
mTOR signaling pathway
|
Ras signaling in the CD4+ TCR pathway
|
ErbB1 downstream signaling
|
PDGFR-beta signaling pathway
|
Signaling events mediated by VEGFR1 and VEGFR2
|
Trk receptor signaling mediated by the MAPK pathway
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
Reactome
|
PIP3 activates AKT signaling
|
Regulation of KIT signaling
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
RAF/MAP kinase cascadeR-HSA-1295596:Spry regulation of FGF signaling
|
Frs2-mediated activation
|
ARMS-mediated activation
|
CREB phosphorylation through the activation of Ras
|
RAF activation
|
MAP2K and MAPK activation
|
Negative feedback regulation of MAPK pathway
|
Negative regulation of MAPK pathway
|
WikiPathways
|
Kit receptor signaling pathway
|
Differentiation Pathway
|
Signaling by SCF-KIT
|
PIP3 activates AKT signaling
|
Cardiac Progenitor Differentiation
|
miR-targeted genes in muscle cell - TarBase
|
miR-targeted genes in lymphocytes - TarBase
|
miR-targeted genes in epithelium - TarBaseWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
Serotonin HTR1 Group and FOS Pathway
|
Estrogen signaling pathway
|
Senescence and Autophagy in Cancer
|
Regulation of Actin Cytoskeleton
|
EGF/EGFR Signaling Pathway
|
MAPK Cascade
|
MAPK Signaling Pathway
|
Focal Adhesion
|
Bladder Cancer
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
Polycystic Kidney Disease Pathway
|
Corticotropin-releasing hormone
|
B Cell Receptor Signaling Pathway
|
Signaling Pathways in Glioblastoma
|
TSH signaling pathway
|
Integrated Breast Cancer Pathway
|
Signaling by FGFR
|
NGF signalling via TRKA from the plasma membrane
|
Integrin-mediated Cell Adhesion
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |