Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX2PET
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| Drug Name |
N-(4-(3-fluorobenzyloxy)-3-(trifluoromethyl)phenyl)-6-(5-((2-(pyridin-2-ylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine
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| Synonyms |
CHEMBL214023
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C34H27F4N5O4S
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| Canonical SMILES |
Fc1cccc(COc2ccc(Nc3ncnc4ccc(cc34)c5oc(CNCCS(=O)(=O)c6ccccn6)cc5)cc2C(F)(F)F)c1
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| InChI |
InChI=1S/C34H27F4N5O4S/c35-24-5-3-4-22(16-24)20-46-31-11-8-25(18-28(31)34(36,37)38)43-33-27-17-23(7-10-29(27)41-21-42-33)30-12-9-26(47-30)19-39-14-15-48(44,45)32-6-1-2-13-40-32/h1-13,16-18,21,39H,14-15,19-20H2,(H,41,42,43)
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| InChIKey |
NXQXZOZVAHCESP-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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