Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX3UCS
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| Drug Name |
1-(4-(4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl)phenyl)-3-cyclohexylurea
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| Synonyms |
CHEMBL195567
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C26H27N5O3
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| Canonical SMILES |
COc1ccc(cc1)c2oc3ncnc(N)c3c2c4ccc(NC(=O)NC5CCCCC5)cc4
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| InChI |
InChI=1S/C26H27N5O3/c1-33-20-13-9-17(10-14-20)23-21(22-24(27)28-15-29-25(22)34-23)16-7-11-19(12-8-16)31-26(32)30-18-5-3-2-4-6-18/h7-15,18H,2-6H2,1H3,(H2,27,28,29)(H2,30,31,32)
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| InChIKey |
CQCCNBVEDUYZMC-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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