Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX4MAR
|
||||
| Drug Name |
4-Dimethylamino-but-2-enoic acid (4-{3-chloro-4-[(naphthalen-1-ylmethyl)-amino]-phenylamino}-3-cyano-7-ethoxy-quinolin-6-yl)-amide
|
||||
| Synonyms |
CHEMBL179766
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C35H33ClN6O2
|
||||
| Canonical SMILES |
CCOc1cc2ncc(C#N)c(Nc3ccc(NCc4cccc5ccccc45)c(Cl)c3)c2cc1NC(=O)\\C=C\\CN(C)C
|
||||
| InChI |
InChI=1S/C35H33ClN6O2/c1-4-44-33-19-31-28(18-32(33)41-34(43)13-8-16-42(2)3)35(25(20-37)22-39-31)40-26-14-15-30(29(36)17-26)38-21-24-11-7-10-23-9-5-6-12-27(23)24/h5-15,17-19,22,38H,4,16,21H2,1-3H3,(H,39,40)(H,41,43)/b13-8+
|
||||
| InChIKey |
IMDOIOFYKKBZEN-MDWZMJQESA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.