Drug General Information
Drug ID
DX4VRQ
Drug Name
N-(4-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-ylamino)phenyl)acetamide
Synonyms
CHEMBL1835865
Indication Discovery agent Investigative [1587926]
Formula
C15H15N7O
Canonical SMILES
CC(=O)Nc1ccc(Nc2nc(N)n(n2)c3ccccn3)cc1
InChI
InChI=1S/C15H15N7O/c1-10(23)18-11-5-7-12(8-6-11)19-15-20-14(16)22(21-15)13-4-2-3-9-17-13/h2-9H,1H3,(H,18,23)(H3,16,19,20,21)
InChIKey
UHENAIWHWGKWLJ-UHFFFAOYSA-N
Target and Pathway
Target(s) FL cytokine receptor Target Info [1587926]
Mast/stem cell growth factor receptor Target Info [1587926]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Melanogenesis
Central carbon metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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