Drug Information

Drug General Information
Drug ID
DX6VBU
Drug Name
N-((2S,4S)-1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)pentan-2-yl)-N-hydroxyformamide
Synonyms
CHEMBL1683443
Indication Discovery agent Investigative [1587926]
Formula
C20H25F2N5O4S
Canonical SMILES
C[C@@H](C[C@@H](CS(=O)(=O)N1CCN(CC1)c2ccc(F)cc2)N(O)C=O)c3ncc(F)cn3
InChI
InChI=1S/C20H25F2N5O4S/c1-15(20-23-11-17(22)12-24-20)10-19(27(29)14-28)13-32(30,31)26-8-6-25(7-9-26)18-4-2-16(21)3-5-18/h2-5,11-12,14-15,19,29H,6-10,13H2,1H3/t15-,19-/m0/s1
InChIKey
KLCHUAUMSZUJEX-KXBFYZLASA-N
Target and Pathway
Target(s) Collagenase 3 Target Info [1587926]
Matrix metalloproteinase-14 Target Info [1587926]
KEGG Pathway TNF signaling pathway
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinghif2pathway:HIF-2-alpha transcription factor network
Signaling events mediated by focal adhesion kinase
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer
Degradation of collagen
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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