Drug General Information |
Drug ID |
DX6Y1L
|
Drug Name |
4-[2-(2-Chloro-phenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-1-methyl-piperidin-3-one
|
Synonyms |
CHEMBL9125
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C21H18ClNO5
|
Canonical SMILES |
CN1CCC(C(=O)C1)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccccc4Cl
|
InChI |
InChI=1S/C21H18ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,24-25H,6-7,10H2,1H3
|
InChIKey |
KAKUQWQNTPPBAA-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Cell division control protein 2 homolog |
Target Info |
|
[1]
|
Cell division protein kinase 4 |
Target Info |
|
[1]
|
KEGG Pathway
|
Cell cycle
|
Oocyte meiosis
|
p53 signaling pathway
|
Gap junction
|
Progesterone-mediated oocyte maturation
|
Herpes simplex infection
|
Epstein-Barr virus infection
|
Viral carcinogenesishsa04110:Cell cycle
|
PI3K-Akt signaling pathway
|
Tight junction
|
T cell receptor signaling pathway
|
Hepatitis B
|
Measles
|
HTLV-I infection
|
Pathways in cancer
|
Viral carcinogenesis
|
Pancreatic cancer
|
Glioma
|
Melanoma
|
Bladder cancer
|
Chronic myeloid leukemia
|
Small cell lung cancer
|
Non-small cell lung cancer
|
NetPath Pathway
|
RANKL Signaling PathwayNetPath_11:TCR Signaling Pathway
|
EGFR1 Signaling Pathway
|
RANKL Signaling Pathway
|
Pathway Interaction Database
|
p73 transcription factor network
|
E2F transcription factor network
|
PLK1 signaling events
|
AP-1 transcription factor network
|
FOXM1 transcription factor network
|
Retinoic acid receptors-mediated signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
Validated targets of C-MYC transcriptional activation
|
ATF-2 transcription factor network
|
Regulation of retinoblastoma protein
|
Reactome
|
MAPK3 (ERK1) activation
|
E2F mediated regulation of DNA replication
|
G0 and Early G1
|
Cyclin B2 mediated events
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
|
Regulation of APC/C activators between G1/S and early anaphase
|
Phosphorylation of the APC/C
|
Phosphorylation of Emi1
|
Condensation of Prophase Chromosomes
|
MASTL Facilitates Mitotic Progression
|
Resolution of Sister Chromatid Cohesion
|
Condensation of Prometaphase Chromosomes
|
Regulation of PLK1 Activity at G2/M Transition
|
Activation of NIMA Kinases NEK9, NEK6, NEK7
|
Loss of Nlp from mitotic centrosomes
|
Recruitment of mitotic centrosome proteins and complexes
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
Recruitment of NuMA to mitotic centrosomes
|
Depolymerisation of the Nuclear Lamina
|
Anchoring of the basal body to the plasma membrane
|
MAPK6/MAPK4 signaling
|
G1/S-Specific Transcription
|
Cyclin A/B1 associated events during G2/M transition
|
G2/M DNA replication checkpoint
|
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-2559580:Oxidative Stress Induced Senescence
|
Senescence-Associated Secretory Phenotype (SASP)
|
Oncogene Induced Senescence
|
RMTs methylate histone arginines
|
Transcriptional regulation of white adipocyte differentiation
|
Ubiquitin-dependent degradation of Cyclin D1
|
Cyclin D associated events in G1
|
Meiotic recombination
|
WikiPathways
|
DNA Damage Response
|
G1 to S cell cycle control
|
TGF beta Signaling Pathway
|
PPAR Alpha Pathway
|
MAP kinase activation in TLR cascade
|
RAF/MAP kinase cascade
|
Mitotic Prophase
|
Mitotic Prometaphase
|
BMI1
|
ATM Signaling Pathway
|
Retinoblastoma (RB) in Cancer
|
Spinal Cord Injury
|
Prostate Cancer
|
Regulation of Microtubule Cytoskeleton
|
Integrated Cancer pathway
|
Mitotic G2-G2/M phases
|
Mitotic G1-G1/S phases
|
Cell Cycle
|
APC/C-mediated degradation of cell cycle proteins
|
Cell Cycle Checkpoints
|
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
|
Ovarian Infertility Genes
|
Bladder Cancer
|
S Phase
|
Transcriptional Regulation of White Adipocyte Differentiation
|
Meiotic Recombination
|
Integrated Pancreatic Cancer Pathway
|
Signaling Pathways in Glioblastoma
|
TSH signaling pathway
|
Integrated Breast Cancer Pathway
|
miRNA Regulation of DNA Damage Response
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |