Drug Information

Drug General Information
Drug ID
DX8HKJ
Drug Name
N-[5-(2-Fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-phenyl-acrylamide: 0.65H2O
Synonyms
CHEMBL443009
Indication Discovery agent Investigative [1587926]
Formula
C24H18FN3O2
Canonical SMILES
Fc1ccccc1C2=NC(NC(=O)\\C=C\\c3ccccc3)C(=O)Nc4ccccc24
InChI
InChI=1S/C24H18FN3O2/c25-19-12-6-4-10-17(19)22-18-11-5-7-13-20(18)26-24(30)23(28-22)27-21(29)15-14-16-8-2-1-3-9-16/h1-15,23H,(H,26,30)(H,27,29)/b15-14+
InChIKey
UXNHLBPVNCIBGP-CCEZHUSRSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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