Drug Information

Drug General Information
Drug ID
DX8IVN
Drug Name
2-3-7-3-4-hydroxymethyl-piperidin-1-yl-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-N-3-trifluoromethyl-phenyl-acetamide
Synonyms
CHEMBL405120
Indication Discovery agent Investigative [1587926]
Formula
C30H34F3N7O4
Canonical SMILES
COc1cc2c(Nc3cc(CC(=O)Nc4cccc(c4)C(F)(F)F)[nH]n3)ncnc2cc1OCCCN5CCC(CO)CC5
InChI
InChI=1S/C30H34F3N7O4/c1-43-25-15-23-24(16-26(25)44-11-3-8-40-9-6-19(17-41)7-10-40)34-18-35-29(23)37-27-13-22(38-39-27)14-28(42)36-21-5-2-4-20(12-21)30(31,32)33/h2,4-5,12-13,15-16,18-19,41H,3,6-11,14,17H2,1H3,(H,36,42)(H2,34,35,37,38,39)
InChIKey
CSIWGLJKPPOVQR-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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