Drug Information

Drug General Information
Drug ID
DX8TZW
Drug Name
CHEMBL215495
Indication Discovery agent Investigative [1587926]
Formula
C27H32FN7O3
Canonical SMILES
CCCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
InChI
InChI=1S/C27H32FN7O3/c1-2-9-35(11-12-36)10-4-13-38-22-7-8-23-24(17-22)29-18-30-27(23)32-25-15-21(33-34-25)16-26(37)31-20-6-3-5-19(28)14-20/h3,5-8,14-15,17-18,36H,2,4,9-13,16H2,1H3,(H,31,37)(H2,29,30,32,33,34)
InChIKey
XQWUFPUUHVVAIM-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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